2. Academic Validation
  3. Discovery of indenopyrazoles as EGFR and VEGFR-2 tyrosine kinase inhibitors by in silico high-throughput screening

Discovery of indenopyrazoles as EGFR and VEGFR-2 tyrosine kinase inhibitors by in silico high-throughput screening

  • Bioorg Med Chem Lett. 2008 Jan 1;18(1):285-8. doi: 10.1016/j.bmcl.2007.10.084.
Taikou Usui 1,  Hyun Seung Ban,  Junpei Kawada,  Takatsugu Hirokawa,  Hiroyuki Nakamura
Affiliations

Affiliation

  • 1 Department of Chemistry, Faculty of Science, Gakushuin University, Tokyo 171-8588, Japan.
PMID: 17983745 DOI: 10.1016/j.bmcl.2007.10.084
Abstract

A series of indenopyrazoles 8 and 9 were designed and synthesized as EGFR tyrosine kinase inhibitors by in silico high-throughput screening. Compounds 8b and 8d showed significant inhibition of A431 cell growth (GI50 = 0.062 and 0.057 microM, respectively). Compounds 8b and 9a showed inhibitory activity toward both EGFR and VEGFR-2 (VEGFR2/KDR/Flk-1) tyrosine kinases, whereas 8d inhibited VEGFR-2 tyrosine kinase, exclusively.

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