2. Academic Validation
  3. Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor

Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor

  • Eur J Med Chem. 2008 Jul;43(7):1519-24. doi: 10.1016/j.ejmech.2007.10.008.
Eun Young Song 1,  Navneet Kaur,  Mi-Young Park,  Yinglan Jin,  Kyeong Lee,  Guncheol Kim,  Ki Youn Lee,  Jee Sun Yang,  Jae Hong Shin,  Ky-Youb Nam,  Kyoung Tai No,  Gyoonhee Han
Affiliations

Affiliation

  • 1 Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yuseong-Gu, Daejeon, Republic of Korea.
PMID: 18023932 DOI: 10.1016/j.ejmech.2007.10.008
Abstract

A series of amide and urea derivatives of benzothiazole have been synthesized and evaluated for their antiproliferative profile in human SK-Hep-1 (liver), MDA-MB-231 (breast), and NUGC-3 (gastric) cell lines. Among them, compounds 1-2, 16-18, 23, and 25-26 had potent to moderate inhibitory activities. Further these compounds were investigated for their ability to inhibit Raf-1 activity.

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