2. Academic Validation
  3. Synthesis, cytotoxic evaluation, and DNA binding of novel thiazolo[5,4-b]quinoline derivatives

Synthesis, cytotoxic evaluation, and DNA binding of novel thiazolo[5,4-b]quinoline derivatives

  • Bioorg Med Chem. 2008 Feb 1;16(3):1142-9. doi: 10.1016/j.bmc.2007.10.084.
Marco A Loza-Mejía 1,  Karina Maldonado-Hernández,  Fernando Rodríguez-Hernández,  Rogelio Rodríguez-Sotres,  Ignacio González-Sánchez,  Angelina Quintero,  José D Solano,  Alfonso Lira-Rocha
Affiliations

Affiliation

  • 1 Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Cd. Universitaria, Coyoacán, México 04510, Mexico.
PMID: 18035542 DOI: 10.1016/j.bmc.2007.10.084
Abstract

A series of novel alkylamino and 9-anilinothiazolo[5,4-b]quinolines were synthesized as potential antitumoral agents. The in vitro cytotoxicity of these compounds was evaluated on several cell lines. The inclusion of electron-withdrawn/acceptor hydrogen-bond groups at position 3' of the anilino ring and the presence of an alkylamino chain on the tricyclic framework (regardless of its position) seem to be structural features relevant to cytotoxic activity.

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