2. Academic Validation
  3. Trypanocidal activity of a new pterocarpan and other secondary metabolites of plants from Northeastern Brazil flora

Trypanocidal activity of a new pterocarpan and other secondary metabolites of plants from Northeastern Brazil flora

  • Bioorg Med Chem. 2008 Feb 15;16(4):1676-82. doi: 10.1016/j.bmc.2007.11.027.
Nashira Campos Vieira 1,  Laila Salmen Espíndola,  Jaime Martins Santana,  Maria Leopoldina Veras,  Otília Deusdênia Loiola Pessoa,  Sávio Moita Pinheiro,  Renata Mendonça de Araújo,  Mary Anne Sousa Lima,  Edilberto Rocha Silveira
Affiliations

Affiliation

  • 1 Laboratório de Farmacognosia, Universidade de Brasília, Brasília, DF, Brazil.
PMID: 18053728 DOI: 10.1016/j.bmc.2007.11.027
Abstract

Two hundred fifteen compounds isolated from Plants of Northeastern Brazil flora have been assayed against epimastigote forms of Trypanosoma cruzi, using the tetrazolium salt MTT as an alternative method. Eight compounds belonging to four different species: Harpalyce brasiliana (Fabaceae), Acnistus arborescens and Physalis angulata (Solanaceae), and Cordia globosa (Boraginaceae) showed significant activity. Among them, a novel and a known pterocarpan, a chalcone, four withasteroids, and a meroterpene benzoquinone were the represented chemical classes.

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