2. Academic Validation
  3. Regiospecific microwave-assisted synthesis and cytotoxic activity against human breast cancer cells of (RS)-6-substituted-7- or 9-(2,3-dihydro-5H-1,4-benzodioxepin-3-yl)-7H- or -9H-purines

Regiospecific microwave-assisted synthesis and cytotoxic activity against human breast cancer cells of (RS)-6-substituted-7- or 9-(2,3-dihydro-5H-1,4-benzodioxepin-3-yl)-7H- or -9H-purines

  • Eur J Med Chem. 2008 Aug;43(8):1742-8. doi: 10.1016/j.ejmech.2007.10.025.
Ana Conejo-García 1,  María C Núñez,  Juan A Marchal,  Fernando Rodríguez-Serrano,  Antonia Aránega,  Miguel A Gallo,  Antonio Espinosa,  Joaquín M Campos
Affiliations

Affiliation

  • 1 Departamento de Química Farmacéutica y Orgánica, Facultad de Farmacia, c/ Campus de Cartuja s/n, 18071 Granada, Spain.
PMID: 18069093 DOI: 10.1016/j.ejmech.2007.10.025
Abstract

Extended studies on the synthesis and pharmacological evaluation of (RS)-6-substituted-7 or 9-(2,3-dihydro-5H-1,4-benzodioxepin-3-yl)-7H- or -9H-purines are presented. The microwave-assisted organic synthesis has provided faster access to the target compounds with the advantage of selective obtaining the N-7' or N-9' regioisomers simplifying their isolation. To test the behaviour of the products (including the purine Bases) on cellular systems, cytotoxic activity against the MCF-7 human breast Cancer cell line was determined, and the three most active compounds were used to study the cell cycle distribution and Apoptosis in the MCF-7 cell line.

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