2. Academic Validation
  3. Octanorcucurbitane and cucurbitane triterpenoids from the tubers of Hemsleya endecaphylla with HIV-1 inhibitory activity

Octanorcucurbitane and cucurbitane triterpenoids from the tubers of Hemsleya endecaphylla with HIV-1 inhibitory activity

  • J Nat Prod. 2008 Jan;71(1):153-5. doi: 10.1021/np0704396.
Jian-Chao Chen 1,  Gao-Hong Zhang,  Zhong-Quan Zhang,  Ming-Hua Qiu,  Yong-Tang Zheng,  Liu-Meng Yang,  Kai-Bei Yu
Affiliations

Affiliation

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan, People's Republic of China.
PMID: 18088099 DOI: 10.1021/np0704396
Abstract

Two new cucurbitacins, endecaphyllacins A (1) and B (2), together with six known analogues (3-8), were isolated from the tubers of Hemsleya endecaphylla. The structures of 1 and 2 were elucidated by NMR and MS spectroscopic analysis. The relative stereochemistry of 1 was determined by single-crystal X-ray diffraction. Compound 4 (cucurbitacin B) showed potent anti-HIV-1 in C8166 cells (EC=0.09 microg/mL) with a selectivity index of 16.7.

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