2. Academic Validation
  3. Diterpenoids from the roots of Suregada glomerulata

Diterpenoids from the roots of Suregada glomerulata

  • J Nat Prod. 2008 Feb;71(2):195-8. doi: 10.1021/np0705211.
Ren-Yi Yan 1,  Yong-Xia Tan,  Xi-Qiang Cui,  Ruo-Yun Chen,  De-Quan Yu
Affiliations

Affiliation

  • 1 Key Laboratory of Bio Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
PMID: 18205316 DOI: 10.1021/np0705211
Abstract

Six new Diterpenoids, 7beta,8alpha-dihydroxy-12-oxo- ent-abietan-16,14-olide ( 1), 3,4,18beta-cyclopropa-7beta,17-dihydroxy- ent-abieta-8(14),13(15)-dien-16,12-olide ( 2), 3alpha,7beta-dihydroxy- ent-abieta-8(14),13(15)-dien-16,12-olide ( 3), 3-oxo-8beta,14beta-epoxy- ent-abieta-11,13(15)-dien-16,12-olide ( 4), 17-hydroxy- ent-pimara-8(14),15-dien-3-one ( 5), and 3alpha,6beta-dihydroxy- ent-kaur-16-ene ( 6), and two known compounds, 7beta-hydroxy- ent-abieta-8(14),13(15)-dien-16,12-olide ( 7) and jolkinolide B, were isolated from roots of Suregada glomerulata. The structures of the new compounds were elucidated on the basis of 1D and 2D NMR and Other spectroscopic studies. The structure of compound 1 was confirmed by X-ray crystallography. Cytotoxic activities were evaluated against five human tumor cell lines.

Figures