2. Academic Validation
  3. Synthesis of 1,2,3-triazole-linked pyrrolobenzodiazepine conjugates employing 'click' chemistry: DNA-binding affinity and anticancer activity

Synthesis of 1,2,3-triazole-linked pyrrolobenzodiazepine conjugates employing 'click' chemistry: DNA-binding affinity and anticancer activity

  • Bioorg Med Chem Lett. 2008 Feb 15;18(4):1468-73. doi: 10.1016/j.bmcl.2007.12.063.
Ahmed Kamal 1,  N Shankaraiah,  V Devaiah,  K Laxma Reddy,  Aarti Juvekar,  Subrata Sen,  Nisha Kurian,  Surekha Zingde
Affiliations

Affiliation

  • 1 Biotransformation Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India.
PMID: 18207392 DOI: 10.1016/j.bmcl.2007.12.063
Abstract

1,2,3-Triazole based molecules are useful pharmacophores for several DNA-alkylating and cross-linking agents. A series of A/C8, C/C2 and A/C8-C/C2-linked 1,2,3-triazole-PBD conjugates have been synthesized by employing 'click' chemistry. These molecules have exhibited promising DNA-binding affinity and Anticancer activity in selected human Cancer cell lines.

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