2. Academic Validation
  3. Tricyclic HIV integrase inhibitors: potent and orally bioavailable C5-aza analogs

Tricyclic HIV integrase inhibitors: potent and orally bioavailable C5-aza analogs

  • Bioorg Med Chem Lett. 2008 Feb 15;18(4):1388-91. doi: 10.1016/j.bmcl.2008.01.018.
Haolun Jin 1,  Matthew Wright,  Richard Pastor,  Michael Mish,  Sammy Metobo,  Salman Jabri,  Rachael Lansdown,  Ruby Cai,  Peter Pyun,  Manuel Tsiang,  Xiaowu Chen,  Choung U Kim
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404, USA.
PMID: 18207398 DOI: 10.1016/j.bmcl.2008.01.018
Abstract

A series of C5-aza tricyclic HIV Integrase inhibitors was prepared. A highly potent and orally bioavailable compound (compound 9) was identified and selected for development.

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