2. Academic Validation
  3. Synthesis and anticancer activity studies of cyclopamine derivatives

Synthesis and anticancer activity studies of cyclopamine derivatives

  • Bioorg Med Chem Lett. 2008 Feb 15;18(4):1359-63. doi: 10.1016/j.bmcl.2008.01.017.
Jianjun Zhang 1,  Massoud Garrossian,  Dale Gardner,  Arash Garrossian,  Young-Tae Chang,  Yun Kyung Kim,  Cheng-Wei Tom Chang
Affiliations

Affiliation

  • 1 Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, UT 84322-0300, USA.
PMID: 18221872 DOI: 10.1016/j.bmcl.2008.01.017
Abstract

A diversity-oriented synthesis has been developed for facile construction of a library of carbohydrate-cyclopamine conjugates. The synthetic protocol is suitable for generating cyclopamine derivatives with various structural motifs for exploring the desired activity. From this initial library, we have observed one derivative that exhibits improved activity against lung Cancer cell as compared to cyclopamine.

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