1. Academic Validation
  2. Two new coumarins from Herpetospermum caudigerum

Two new coumarins from Herpetospermum caudigerum

  • Chem Pharm Bull (Tokyo). 2008 Feb;56(2):192-3. doi: 10.1248/cpb.56.192.
Mei Zhang 1 Yun Deng Hong-Bin Zhang Xiao-Lin Su Hu-Lan Chen Tian Yu Ping Guo
Affiliations

Affiliation

  • 1 College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, PR China. zhangmei63@yahoo.com.cn
Abstract

The ethyl acetate extract from the seeds of Herpetospermum caudigerum was found to show protective effects on carbon tetrachloride (CCl(4)) and thioacetamide (TAA)-induced acute hepatic injuries in mice. From the ethyl acetate extract, two new Coumarins, herpetolide A (1) and herpetolide B (2), along with four known compounds, herpetone (3), dehydrodiconiferyl alcohol (4), 2,4-dihydroxypyrimidine (5) and stigmasterol (6) were isolated. The structures of the new Coumarins were elucidated on the basis of chemical and physicochemical evidences. Herpetone exhibited protective effects on CCl(4)-induced hepatocyte injury.

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