2. Academic Validation
  3. The total synthesis of fukiic acid, an HIV-1 integrase inhibitor

The total synthesis of fukiic acid, an HIV-1 integrase inhibitor

  • Eur J Med Chem. 2008 Oct;43(10):2268-71. doi: 10.1016/j.ejmech.2007.12.013.
Clémence Queffélec 1,  Fabrice Bailly,  Gladys Mbemba,  Jean-François Mouscadet,  Zeger Debyser,  Myriam Witvrouw,  Philippe Cotelle
Affiliations

Affiliation

  • 1 Laboratoire de Chimie Organique et Macromoléculaire, CNRS UMR 8009, Université de Lille 1, 59655 Villeneuve d'Ascq, France.
PMID: 18243421 DOI: 10.1016/j.ejmech.2007.12.013
Abstract

A successful synthesis of fukiic acid is described in 7% overall yield (6 steps from veratraldehyde). rac-Fukiic acid was found to be a potent inhibitor of HIV-1 integrase but did not reveal any Antiviral activity in the MT-4 cells assay.

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