2. Academic Validation
  3. Sesquiterpene quinones and related metabolites from Phyllosticta spinarum, a fungal strain endophytic in Platycladus orientalis of the Sonoran Desert

Sesquiterpene quinones and related metabolites from Phyllosticta spinarum, a fungal strain endophytic in Platycladus orientalis of the Sonoran Desert

  • J Nat Prod. 2008 Feb;71(2):218-22. doi: 10.1021/np070600c.
E M Kithsiri Wijeratne 1,  Priyani A Paranagama,  Marilyn T Marron,  Malkanthi K Gunatilaka,  A Elizabeth Arnold,  A A Leslie Gunatilaka
Affiliations

Affiliation

  • 1 SW Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, University of Arizona, 250 E. Valencia Road, Tucson, Arizona 85706-6800, USA.
PMID: 18247573 DOI: 10.1021/np070600c
Abstract

Five new metabolites, (+)-(5 S,10 S)-4'-hydroxymethylcyclozonarone ( 1), 3-ketotauranin ( 3), 3alpha-hydroxytauranin ( 4), 12-hydroxytauranin ( 5), and phyllospinarone ( 6), together with tauranin ( 2), were isolated from Phyllosticta spinarum, a Fungal strain endophytic in Platycladus orientalis. The structures of the new compounds were determined on the basis of their 1D and 2D NMR spectroscopic data and chemical interconversions. All compounds were evaluated for inhibition of cell proliferation in a panel of five Cancer cell lines, and only tauranin ( 2) showed activity. When tested in a flow cytometry-based assay, tauranin induced Apoptosis in PC-3M and NIH 3T3 cell lines.

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