Dichapetalin-type triterpenoids and lignans from the aerial parts of Phyllanthus acutissima

J Nat Prod. 2008 Apr;71(4):655-63. doi: 10.1021/np7007347.

Patoomratana Tuchinda ¹, Jittra Kornsakulkarn, Manat Pohmakotr, Palangpon Kongsaeree, Samran Prabpai, Chalobon Yoosook, Jitra Kasisit, Chanita Napaswad, Samaisukh Sophasan, Vichai Reutrakul

Affiliations

Affiliation

1 Department of Chemistry, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand. scptc@mahidol.ac.th

PMID: 18271551 DOI: 10.1021/np7007347

Abstract

Chemical investigation of the aerial parts of Phyllanthus acutissima resulted in the isolation of five new dichapetalin-type triterpenoids, acutissimatriterpenes A-E ( 1- 5), and two new Lignans, acutissimalignans A ( 6) and B ( 7), along with two known Lignans and three known ellagic acid derivatives. The structures of 1- 7 were determined mainly on the basis of spectroscopic methods. The compounds obtained were evaluated for cytotoxic and anti-HIV-1 activities.

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