2. Academic Validation
  3. Potent inhibitors of the hedgehog signaling pathway

Potent inhibitors of the hedgehog signaling pathway

  • J Med Chem. 2008 Mar 13;51(5):1108-10. doi: 10.1021/jm070694n.
Shirley A Brunton 1,  John H A Stibbard,  Lee L Rubin,  Lawrence I Kruse,  Oivin M Guicherit,  Edward A Boyd,  Steven Price
Affiliations

Affiliation

  • 1 Evotec, Oxfordshire, UK. shirley.brunton@evotec.com
PMID: 18275133 DOI: 10.1021/jm070694n
Abstract

A small family of phenyl quinazolinone ureas is reported as potent modulators of Hedgehog protein function. Preliminary SAR studies of the urea substituent led to a nanomolar Hedgehog antagonist.

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