2. Academic Validation
  3. Anti-BK virus activity of nucleoside analogs

Anti-BK virus activity of nucleoside analogs

  • Antimicrob Agents Chemother. 2008 Apr;52(4):1519-21. doi: 10.1128/AAC.01241-07.
Parmjeet Randhawa 1,  Jiri Zemlicka,  Andreas Sauerbrei,  Chris Meier,  Karl Y Hostetler,  James R Beadle,  Noush Afarin Farasati,  Yuchen Huang,  Matthews Bradley
Affiliations

Affiliation

  • 1 Division of Transplantation Pathology, Department of Pathology, University of Pittsburgh, Room Medical Center, Pittsburgh, PA 15213, USA. randhawapa@upmc.edu
PMID: 18285481 DOI: 10.1128/AAC.01241-07
Abstract

Polyomavirus BK is an important pathogen in transplant recipients with no effective therapy. This study demonstrates that alkoxyalkyl esters of (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and fatty acid derivatives of 9-[2-(phosphonomethyoxy)ethyl]adenine (P393 and P405) are potent and selective inhibitors of BK virus replication in vitro, with a 50% effective concentration in the micromolar-to-nanomolar range.

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