2. Academic Validation
  3. Studies on quinones. Part 43: Synthesis and cytotoxic evaluation of polyoxyethylene-containing 1,4-naphthoquinones

Studies on quinones. Part 43: Synthesis and cytotoxic evaluation of polyoxyethylene-containing 1,4-naphthoquinones

  • Bioorg Med Chem. 2008 Apr 1;16(7):3687-93. doi: 10.1016/j.bmc.2008.02.018.
Jaime A Valderrama 1,  Hilda Leiva,  Jaime A Rodríguez,  Cristina Theoduloz,  Guillermo Schmeda-Hirshmann
Affiliations

Affiliation

  • 1 Facultad de Quimica, Pontificia Universidad Católica de Chile, Casilla 306, Vicuna Machenna, 4860 Santiago, Chile. jvalderr@uc.cl
PMID: 18299197 DOI: 10.1016/j.bmc.2008.02.018
Abstract

A series of naphthoquinones 2,3-disubstituted with chlorine and oxyethylene groups have been prepared from 2,3-dichloro- and 2,3-dimethoxy-1,4-naphthoquinone. The members of these series were tested on normal human fibroblasts and on a panel of four human Cancer cell lines. Antitumor activities, which were in the range of IC(50) 1.3-89.5 microM, discussed in terms of LUMO energy, lipophilicity and size of the polyoxyethylene moiety.

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