2. Academic Validation
  3. Pestalotheols A-D, bioactive metabolites from the plant endophytic fungus Pestalotiopsis theae

Pestalotheols A-D, bioactive metabolites from the plant endophytic fungus Pestalotiopsis theae

  • J Nat Prod. 2008 Apr;71(4):664-8. doi: 10.1021/np700744t.
Erwei Li 1,  Renrong Tian,  Shuchun Liu,  Xulin Chen,  Liangdong Guo,  Yongsheng Che
Affiliations

Affiliation

  • 1 Key Laboratory of Systematic Mycology and Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100080, People's Republic of China.
PMID: 18303847 DOI: 10.1021/np700744t
Abstract

Pestalotheols A-D ( 1- 4 ), four new metabolites, have been isolated from cultures of an isolate of the plant endophytic fungus Pestalotiopsis theae. The structures of these compounds were determined by NMR spectroscopy, and 1 is further confirmed by X-ray crystallography. The absolute configurations of compounds 1 and 3 were assigned by application of the modified Mosher method. Pestalotheol C ( 3) displayed an inhibitory effect on HIV-1 LAI replication in C8166 cells with an EC 50 value of 16.1 microM.

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