2. Academic Validation
  3. Interactions of DB75, a novel antimalarial agent, with other antimalarial drugs in vitro

Interactions of DB75, a novel antimalarial agent, with other antimalarial drugs in vitro

  • Antimicrob Agents Chemother. 2008 Jun;52(6):2253-5. doi: 10.1128/AAC.01536-07.
Anne E Purfield 1,  Richard R Tidwell,  Steven R Meshnick
Affiliations

Affiliation

  • 1 Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599-7435, USA.
PMID: 18362196 DOI: 10.1128/AAC.01536-07
Abstract

Pafuramidine is a novel orally active antimalarial. To identify a combination partner, we measured the in vitro antimalarial activities of the active metabolite, DB75, with amodiaquine, artemisinin, atovaquone, azithromycin, chloroquine, clindamycin, mefloquine, piperaquine, pyronaridine, tafenoquine, and Tetracycline. None of the drugs tested demonstrated antagonistic or synergistic activity in combination with pafuramidine.

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