2. Academic Validation
  3. Phenolic glycosides from the filamentous fungus Acremonium sp. BCC 14080

Phenolic glycosides from the filamentous fungus Acremonium sp. BCC 14080

  • J Nat Prod. 2008 May;71(5):891-4. doi: 10.1021/np070689m.
Taridaporn Bunyapaiboonsri 1,  Seangaroon Yoiprommarat,  Artit Khonsanit,  Somjit Komwijit
Affiliations

Affiliation

  • 1 National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, Klong 1, Klong Luang, Pathumthani, Thailand. taridaporn@biotec.or.th
PMID: 18363379 DOI: 10.1021/np070689m
Abstract

New phenolic mono- and digalactopyranosides (1 and 2), their aglycone KS-501a (3), and a new phenolic 4-O-methylglucopyranoside (4) were isolated from the filamentous fungus Acremonium sp. BCC 14080. Structures of these compounds were elucidated by extensive MS and NMR spectroscopic analyses. Compound 1 displayed anti-HSV-1 activity with an IC(50) value of 7.2 microM. Compound 3 exhibited activity against Plasmodium falciparum K1 with an IC(50) value of 9.9 microM.

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