2. Academic Validation
  3. Novel bisbenzimidazoles with antileishmanial effectiveness

Novel bisbenzimidazoles with antileishmanial effectiveness

  • Bioorg Med Chem Lett. 2008 Apr 15;18(8):2658-61. doi: 10.1016/j.bmcl.2008.03.020.
Annie Mayence 1,  Aurélie Pietka,  Margaret S Collins,  Melanie T Cushion,  Babu L Tekwani,  Tien L Huang,  Jean Jacques Vanden Eynde
Affiliations

Affiliation

  • 1 Xavier University of Louisiana, College of Pharmacy, Division of Basic Pharmaceutical Sciences, 1 Drexel Drive, New Orleans, LA 70125, USA.
PMID: 18367395 DOI: 10.1016/j.bmcl.2008.03.020
Abstract

A small library of 2,2'-[(alpha,omega-alkanediylbis(oxyphenylene)]bis-1H-benzimidazoles has been prepared and screened in vitro against Pneumocystis carinii, Trypanosoma brucei rhodesiense, and Leishmania donovani. Among the six tested compounds two derivatives emerged as promising hits characterized by IC(50) values lower than that determined for pentamidine against L. donovani.

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