2. Academic Validation
  3. Antiproliferative oleanane saponins from Meryta denhamii

Antiproliferative oleanane saponins from Meryta denhamii

  • J Nat Prod. 2008 Jun;71(6):1000-4. doi: 10.1021/np8000464.
Giuseppina Cioffi 1,  Fabrizio Dal Piaz,  Antonio Vassallo,  Fabio Venturella,  Paolo De Caprariis,  Francesco De Simone,  Nunziatina De Tommasi
Affiliations

Affiliation

  • 1 Dipartimento di Scienze Farmaceutiche, Universitaàdi Salerno, Via Ponte Don Melillo, 84084 Fisciano (SA), Italy.
PMID: 18442289 DOI: 10.1021/np8000464
Abstract

Eight new oleanane saponins (1- 8) together with four know saponins (9-12) were isolated from the aerial parts of Meryta denhamii. Their structures were elucidated by 1D and 2D NMR experiments including 1D TOCSY, DQF-COSY, ROESY, HSQC, and HMBC spectroscopy, as well as ESIMS analysis. The antiproliferative activity of all compounds was evaluated using three murine and human Cancer cell lines: J774.A1, HEK-293, and WEHI-164.

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