2. Academic Validation
  3. 3,5-Dihydro-imidazo[4,5-d]pyridazin-4-ones: a class of potent DPP-4 inhibitors

3,5-Dihydro-imidazo[4,5-d]pyridazin-4-ones: a class of potent DPP-4 inhibitors

  • Bioorg Med Chem Lett. 2008 Jun 1;18(11):3158-62. doi: 10.1016/j.bmcl.2008.04.075.
Matthias Eckhardt 1,  Norbert Hauel,  Frank Himmelsbach,  Elke Langkopf,  Herbert Nar,  Michael Mark,  Moh Tadayyon,  Leo Thomas,  Brian Guth,  Ralf Lotz
Affiliations

Affiliation

  • 1 Department of Chemical Research, Boehringer Ingelheim Pharma GmbH & Co. KG, 88400 Biberach, Germany. matthias.eckhardt@boehringer-ingelheim.com
PMID: 18485703 DOI: 10.1016/j.bmcl.2008.04.075
Abstract

Systematic variations of the xanthine scaffold in close analogs of development compound BI 1356 led to the class of 3,5-dihydro-imidazo[4,5-d]pyridazin-4-ones which provided, after substituent screening, a series of highly potent DPP-4 inhibitors.

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