2. Academic Validation
  3. Microbial transformation of cinobufagin by Syncephalastrum racemosum

Microbial transformation of cinobufagin by Syncephalastrum racemosum

  • J Nat Prod. 2008 Jul;71(7):1268-70. doi: 10.1021/np800210a.
Xiao-chi Ma 1,  Xiu-lan Xin,  Ke-xin Liu,  Jian Han,  De-an Guo
Affiliations

Affiliation

  • 1 The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, People's Republic of China.
PMID: 18558746 DOI: 10.1021/np800210a
Abstract

Microbial transformation of a cytotoxic bufadienolide, cinobufagin (1), was performed by Syncephalastrum racemosum. The six metabolites obtained were identified as 7beta-hydroxycinobufagin ( 2), 12beta-hydroxycinobufagin (3), cinobufotalin (4), 5,12beta-dihydroxycinobufagin (5), 4beta,11alpha-dihydroxycinobufagin (6), and 4beta,12alpha-dihydroxycinobufagin (7), respectively, on the basis of spectroscopic studies. Metabolites 2 and 5-7 were characterized as new compounds, and 2-7 proved to be cytotoxic against Bel-7402 human hepatoma cells.

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