2. Academic Validation
  3. T-type Ca2+ channel blockers suppress the growth of human cancer cells

T-type Ca2+ channel blockers suppress the growth of human cancer cells

  • Bioorg Med Chem Lett. 2008 Jul 15;18(14):3899-901. doi: 10.1016/j.bmcl.2008.06.034.
Jae Ho Heo 1,  Han Na Seo,  Yun Jeong Choe,  Sujin Kim,  Chun Rim Oh,  Young Deuk Kim,  Hyewhon Rhim,  Dong Joon Choo,  Jungahn Kim,  Jae Yeol Lee
Affiliations

Affiliation

  • 1 Research Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University, 1 Hoegi-Dong, Dongdaemun-Gu, Seoul 130-701, Republic of Korea.
PMID: 18585035 DOI: 10.1016/j.bmcl.2008.06.034
Abstract

In order to further clarify the role of T-type CA(2+) channels in cell proliferation, we have measured the growth inhibition of human Cancer cells by using our potent T-type CA(2+) channel blockers. As a result, KYS05090, a most potent T-type CA(2+) channel blocker, was found to be as potent as doxorubicin against some human Cancer cells without acute toxicity. Therefore, this letter provides the biological results that T-type calcium channel is important in regulating the important cellular phenotype transition leading to cell proliferation, and thus novel T-type CA(2+) channel blocker presents new prospects for Cancer treatment.

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