2. Academic Validation
  3. Synthesis and biological evaluation of cytotoxic properties of stilbene-based resveratrol analogs

Synthesis and biological evaluation of cytotoxic properties of stilbene-based resveratrol analogs

  • Eur J Med Chem. 2009 Feb;44(2):701-7. doi: 10.1016/j.ejmech.2008.05.003.
Dênis Pires de Lima 1,  Rodrigo Rotta,  Adilson Beatriz,  Maria Rita Marques,  Raquel C Montenegro,  Marne C Vasconcellos,  Cláudia Pessoa,  Manoel O de Moraes,  Letícia V Costa-Lotufo,  Alexandra Christine Helena Frankland Sawaya,  Marcos Nogueira Eberlin
Affiliations

Affiliation

  • 1 Departamento de Química, Universidade Federal de Mato Grosso do Sul, CP 549, 79070-900 Campo Grande, MS, Brazil. dlima@nin.ufms.br
PMID: 18586355 DOI: 10.1016/j.ejmech.2008.05.003
Abstract

This work deals with the preparation of stilbene-based resveratrol analogs by employing the Perkin reaction, aiming at synthesizing potential antitumor lead compounds and evaluating their pharmacological activities. The proliferation inhibitor test against tumor cell lines identified analogs 9 and 11 as the most active among all synthesized derivatives, presenting IC(50) in micromolar range for certain cell lines. For study on the embryonic development, compounds 8 and 9 at the lowest tested concentration (41.7 microM) that inhibited sea urchin egg development, but only after third cleavage were used. Both the compounds inhibited 100% of normal development since first cleavage. These data partially corroborated the results obtained with MTT assay using tumor cell lines. None of the tested compounds revealed hemolytic action in assay with mouse erythrocytes.

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