Cucurbitane-type triterpenoids from the stems of momordica charantia

J Nat Prod. 2008 Aug;71(8):1327-30. doi: 10.1021/np070532u.

Chi-I Chang ¹, Chiy-Rong Chen, Yun-Wen Liao, Hsueh-Ling Cheng, Yo-Chia Chen, Chang-Hung Chou

Affiliations

Affiliation

1 Graduate Institute of Biotechnology, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan, Republic of China.

PMID: 18637688 DOI: 10.1021/np070532u

Abstract

Four new cucurbitane-type Triterpenes, cucurbita-5,23(E)-diene-3beta,7beta,25-triol (1), 3beta-acetoxy-7beta-methoxycucurbita-5,23(E)-dien-25-ol (2), cucurbita-5(10),6,23(E)-triene-3beta,25-diol (5), and cucurbita-5,24-diene-3,7,23-trione (6), together with four known Triterpenes, 3beta,25-dihydroxy-7beta-methoxycucurbita-5,23(E)-diene (3), 3beta-hydroxy-7beta,25-dimethoxycucurbita-5,23(E)-diene (4), 3beta,7beta,25-trihydroxycucurbita-5,23(E)-dien-19-al (7), and 25-methoxy-3beta,7beta-dihydroxycucurbita-5,23(E)-dien-19-al (8), were isolated from the methyl alcohol extract of the stems of Momordica charantia. The structures of the new compounds were elucidated by spectroscopic methods.

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