2. Academic Validation
  3. Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors

Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors

  • J Med Chem. 2008 Aug 28;51(16):5125-9. doi: 10.1021/jm8003784.
Serena Pasquini 1,  Claudia Mugnaini,  Cristina Tintori,  Maurizio Botta,  Alejandro Trejos,  Riina K Arvela,  Mats Larhed,  Myriam Witvrouw,  Martine Michiels,  Frauke Christ,  Zeger Debyser,  Federico Corelli
Affiliations

Affiliation

  • 1 Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi di Siena, Via A. Moro, 53100 Siena, Italy.
PMID: 18665580 DOI: 10.1021/jm8003784
Abstract

A set of 4-quinolone-3-carboxylic acids bearing different substituents on the condensed benzene ring was designed and synthesized as potential HIV-1 integrase inhibitors structurally related to elvitegravir. Some of the new compounds proved to be able to inhibit the strand transfer step of the virus integration process in the micromolar range. Docking studies and quantum mechanics calculations were used to rationalize these data.

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