Frajunolides E-K, briarane diterpenes from Junceella fragilis

J Nat Prod. 2008 Sep;71(9):1551-6. doi: 10.1021/np800126f.

Chia-Ching Liaw ¹, Ya-Ching Shen, Yun-Sheng Lin, Tsong-Long Hwang, Yao-Haur Kuo, Ashraf Taha Khalil

Affiliations

Affiliation

1 Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan, Republic of China.

PMID: 18774864 DOI: 10.1021/np800126f

Abstract

Chemical investigation of the gorgonian octocoral Junceella fragilis, collected in Taiwan, resulted in the isolation of seven new briarane-type diterpenes, frajunolides E-K (1-7), in addition to 14 known briaranes, praelolide, junceellin, junceellolides A-E, and K, 11a,20a-epoxy-4-deacetoxyjunceelolide D, umbraculolide A, junceellonoid A, and juncins Y, Z, and ZI, as well as ergosterol peroxide. The structures of 1-7 were determined by analysis of HRESIMS and 2D NMR spectroscopic data. Cytotoxicity and in vitro anti-inflammatory activities of compounds 1-7 were also evaluated.

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