2. Academic Validation
  3. Synthesis and antiproliferative activity of unnatural enantiomers of 7-epi-goniofufurone and crassalactone C

Synthesis and antiproliferative activity of unnatural enantiomers of 7-epi-goniofufurone and crassalactone C

  • Bioorg Med Chem Lett. 2008 Oct 1;18(19):5178-81. doi: 10.1016/j.bmcl.2008.08.093.
Velimir Popsavin 1,  Goran Benedeković,  Bojana Srećo,  Mirjana Popsavin,  Jovana Francuz,  Vesna Kojić,  Gordana Bogdanović
Affiliations

Affiliation

  • 1 Department of Chemistry, Faculty of Sciences, University of Novi Sad, Trg D. Obradovića 3, 21000 Novi Sad, Serbia. popsavin@ih.ns.ac.yu
PMID: 18783950 DOI: 10.1016/j.bmcl.2008.08.093
Abstract

A facile synthesis of 7-epi-(-)-goniofufurone as well as the first synthesis of (-)-crassalactone C was achieved starting from D-xylose. A comparison of their in vitro antitumour activities with those observed for the corresponding naturally occurring enantiomers was provided.

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