2. Academic Validation
  3. Towards novel S-DABOC inhibitors: synthesis, biological investigation, and molecular modeling studies

Towards novel S-DABOC inhibitors: synthesis, biological investigation, and molecular modeling studies

  • Bioorg Med Chem Lett. 2008 Nov 1;18(21):5777-80. doi: 10.1016/j.bmcl.2008.09.070.
Marco Radi 1,  Lucilla Angeli,  Luigi Franchi,  Lorenzo Contemori,  Giovanni Maga,  Alberta Samuele,  Samantha Zanoli,  Mercedes Armand-Ugon,  Emmanuel Gonzalez,  Anuska Llano,  Jose A Esté,  Maurizio Botta
Affiliations

Affiliation

  • 1 Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi di Siena, Via Alcide de Gasperi 2, I-53100 Siena, Italy.
PMID: 18842407 DOI: 10.1016/j.bmcl.2008.09.070
Abstract

A small family of S-DABO cytosine analogs (S-DABOCs) has been synthesized and biologically evaluated as HIV-1 Inhibitor both on wild type (wt) and drug-resistant mutants leading to the identification of an interesting compound (5d). Molecular modeling studies have been finally performed in order to rationalize the results.

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