2. Academic Validation
  3. A diaminocyclohexyl analog of SNS-032 with improved permeability and bioavailability properties

A diaminocyclohexyl analog of SNS-032 with improved permeability and bioavailability properties

  • Bioorg Med Chem Lett. 2008 Nov 1;18(21):5763-5. doi: 10.1016/j.bmcl.2008.09.073.
Ingrid C Choong 1,  Iana Serafimova,  Junfa Fan,  David Stockett,  Erica Chan,  Sravanthi Cheeti,  Yafan Lu,  Bruce Fahr,  Phuongly Pham,  Michelle R Arkin,  Duncan H Walker,  Ute Hoch
Affiliations

Affiliation

  • 1 Medicinal Chemistry, Sunesis Pharmaceuticals, South San Francisco, CA 94080, USA. ichoong2@gmail.com
PMID: 18842409 DOI: 10.1016/j.bmcl.2008.09.073
Abstract

The identification of a selective CDK2, 7, 9 inhibitor 4 with improved permeability is described. Compound 4 exhibits comparable CDK selectivity profile to SNS-032, but shows improved permeability and higher bioavailability in mice.

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