2. Academic Validation
  3. Pestalazines and pestalamides, bioactive metabolites from the plant pathogenic fungus Pestalotiopsis theae

Pestalazines and pestalamides, bioactive metabolites from the plant pathogenic fungus Pestalotiopsis theae

  • J Nat Prod. 2008 Nov;71(11):1861-5. doi: 10.1021/np800357g.
Gang Ding 1,  Lihua Jiang,  Liangdong Guo,  Xulin Chen,  Hua Zhang,  Yongsheng Che
Affiliations

Affiliation

  • 1 Key Laboratory of Systematic Mycology & Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, People's Republic of China.
PMID: 18855443 DOI: 10.1021/np800357g
Abstract

Pestalazines A (1) and B (2), two new diketopiperazine heterodimers, and pestalamides A-C (3-5), three new amides, have been isolated from cultures of the plant pathogenic fungus Pestalotiopsis theae. The structures of these compounds were elucidated mainly by NMR spectroscopy. The absolute configurations of 1 and 2 were determined using Marfey's method on their acid hydrolysates and by comparison of their CD spectra with that of a model compound. Compounds 1, 3, and 6 displayed inhibitory effects on HIV-1 replication in C8166 cells. Compound 3 also showed potent Antifungal activity against Aspergillus fumigatus.

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