2. Academic Validation
  3. Modifications of the isonipecotic acid fragment of SNS-032: analogs with improved permeability and lower efflux ratio

Modifications of the isonipecotic acid fragment of SNS-032: analogs with improved permeability and lower efflux ratio

  • Bioorg Med Chem Lett. 2008 Dec 1;18(23):6236-9. doi: 10.1016/j.bmcl.2008.09.099.
Junfa Fan 1,  Bruce Fahr,  David Stockett,  Erica Chan,  Sravanthi Cheeti,  Iana Serafimova,  Yafan Lu,  Phuongly Pham,  Duncan H Walker,  Ute Hoch,  Ingrid C Choong
Affiliations

Affiliation

  • 1 Sunesis Pharmaceuticals, 341 Oyster Point Blvd, South San Francisco, CA 94080, USA. jfan@sunesis.com
PMID: 18926699 DOI: 10.1016/j.bmcl.2008.09.099
Abstract

Modifications of the isonipecotic acid fragment of SNS-032 results in analogs which are more permeable and lower effluxed than SNS-032. The enantiomerically pure synthesis and the in vivo profile of analog 20 is described.

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