2. Academic Validation
  3. Oxidative burst inhibitory and cytotoxic indoloquinazoline and furoquinoline alkaloids from Oricia suaveolens

Oxidative burst inhibitory and cytotoxic indoloquinazoline and furoquinoline alkaloids from Oricia suaveolens

  • J Nat Prod. 2008 Nov;71(11):1942-5. doi: 10.1021/np800276f.
Jean Duplex Wansi 1,  M Ahmed Mesaik,  David Dako Chiozem,  Krishna Prasad Devkota,  Nicolas Gaboriaud-Kolar,  Marie-Christine Lallemand,  Jean Wandji,  M Iqbal Choudhary,  Norbert Sewald
Affiliations

Affiliation

  • 1 Department of Chemistry, University of Douala, Faculty of Science, P.O. Box 24157 Douala, Cameroon. jdwansi@yahoo.fr
PMID: 18950230 DOI: 10.1021/np800276f
Abstract

Two new β-indoloquinazoline Alkaloids, orisuaveoline A (1) and orisuaveoline B (2), two new furoquinoline Alkaloids, quinosuaveoline A (5) and quinosuaveoline B (6), and 12 known compounds were isolated from Oricia suaveolens. The structures of the new compounds were deduced by spectroscopic studies. The absolute configuration of nkolbisine (4) was also determined. Compounds 2, 3, 6-8, 10, and 14 were evaluated for oxidative burst inhibitory activity in a chemoluminescence assay and for cytotoxicity against A549 lung carcinoma cells.

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