2. Academic Validation
  3. Novel 3-phenylpropane-1,2-diamine derivates as inhibitors of aminopeptidase N (APN)

Novel 3-phenylpropane-1,2-diamine derivates as inhibitors of aminopeptidase N (APN)

  • Bioorg Med Chem. 2008 Dec 1;16(23):9984-90. doi: 10.1016/j.bmc.2008.10.025.
Luqing Shang 1,  Qiang Wang,  Hao Fang,  Jiajia Mu,  Xuejian Wang,  Yumei Yuan,  Binghe Wang,  Wenfang Xu
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, School of Pharmacy, Shandong University, 44 West Culture Road, 250012 Ji'nan, Shandong, PR China.
PMID: 18996018 DOI: 10.1016/j.bmc.2008.10.025
Abstract

Aminopeptidase N (APN) is an essential peptidase involved in the process of tumor invasion and metastasis. Here we describe a novel class of inhibitor with 3-phenylpropane-1,2-diamine as scaffold to APN. Preliminary activity evaluation with Enzyme inhibition studies showed that compound 12i exhibited potent and selective inhibitory activity towards APN with the IC(50) value 15.5+/-1.2microM.

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