2. Academic Validation
  3. 11-Phenyl-[b,e]-dibenzazepine compounds: novel antitumor agents

11-Phenyl-[b,e]-dibenzazepine compounds: novel antitumor agents

  • Bioorg Med Chem Lett. 2009 Jan 1;19(1):104-7. doi: 10.1016/j.bmcl.2008.11.001.
Raed A Al-Qawasmeh 1,  Yoon Lee,  Ming-Yu Cao,  Xiaoping Gu,  Stéphane Viau,  Jeff Lightfoot,  Jim A Wright,  Aiping H Young
Affiliations

Affiliation

  • 1 Department of Chemistry, The University of Jordan, Amman, Jordan.
PMID: 19027297 DOI: 10.1016/j.bmcl.2008.11.001
Abstract

A series of 11-phenyl-[b,e]-dibenzazepine compounds were synthesized and shown to be inhibitors of tumor cell proliferation with IC(50) values ranging from submicromolar to micromolar concentrations. Flow cytometric analyses of several active compounds demonstrated inhibition of cell cycle progression at the G(0)-G(1) phase transition resulting in G(0)-G(1) arrest.

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