2. Academic Validation
  3. Sesquiterpene lactones from Gonospermum gomerae and G. fruticosum and their cytotoxic activities

Sesquiterpene lactones from Gonospermum gomerae and G. fruticosum and their cytotoxic activities

  • J Nat Prod. 2008 Dec;71(12):2015-20. doi: 10.1021/np800474v.
Jorge Triana 1,  José Luis Eiroa,  Juan José Ortega,  Francisco León,  Ignacio Brouard,  Fernando Torres,  José Quintana,  Francisco Estévez,  Jaime Bermejo
Affiliations

Affiliation

  • 1 Departamento de Química, Universidad de Las Palmas de Gran Canaria, Campus de Tafira, 35017 Las Palmas de Gran Canaria, Canary Islands, Spain.
PMID: 19053514 DOI: 10.1021/np800474v
Abstract

Four new sesquiterpene lactones (1-4) and a new sesquiterpene (5) together with 20 known compounds were isolated from two Gonospermum species (G. gomerae Bolle and G. fruticosum Less). Their structures were determined by analysis of spectroscopic data, including 1D and 2D NMR. The cytotoxicity of several new and known natural and semisynthetic sesquiterpene lactones was also assessed against human myeloid leukemia cell lines (HL-60 and U937), human melanoma cells (SK-MEL-1), and human adenocarcinoma (A549).

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