Identification and physiological evaluation of the components from citrus fruits as potential drugs for anti-corpulence and anticancer

Bioorg Med Chem. 2009 Jan 1;17(1):25-8. doi: 10.1016/j.bmc.2008.11.039.

Toshifumi Hirata ¹, Misato Fujii, Kazuhiro Akita, Noriyuki Yanaka, Kaori Ogawa, Masanori Kuroyanagi, Daiki Hongo

Affiliations

Affiliation

1 Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima 739-8526, Japan. hirata-001@hiroshima-u.ac.jp

PMID: 19054677 DOI: 10.1016/j.bmc.2008.11.039

Abstract

On the basis of monitoring the prevention of accumulation of lipid droplets in mouse 3T3-L1 preadipocyte cells and inhibition of the proliferation of human colon Cancer HT-29 cells, effective anti-corpulence and Anticancer compounds were isolated from the peel of Citrus fruits. These bioactive components were identified as polymethoxyflavones and coumarin derivatives by spectroscopic analyses. 5-Hydroxy-6,7,8,3',4'-pentamethoxyflavone had the greatest anti-corpulence effects and 3,5,6,7,8,3',5'-heptamethoxyflavone had the greatest Anticancer effects. Furthermore, distributions of those bioactive components in the peel of 10 species of Citrus fruits were demonstrated by HPLC analyses.

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