2. Academic Validation
  3. 3-Hydroxyisoquinolines as inhibitors of HCV NS5b RNA-dependent RNA polymerase

3-Hydroxyisoquinolines as inhibitors of HCV NS5b RNA-dependent RNA polymerase

  • Bioorg Med Chem Lett. 2009 Jan 15;19(2):410-4. doi: 10.1016/j.bmcl.2008.11.060.
Robert T Hendricks 1,  Stacey R Spencer,  James F Blake,  Jay B Fell,  John P Fischer,  Peter J Stengel,  Vincent J P Leveque,  Sophie Lepogam,  Sonal Rajyaguru,  Isabel Najera,  John A Josey,  Steven Swallow
Affiliations

Affiliation

  • 1 Roche Palo Alto LLC, Medicinal Chemistry, 3431 Hillview Avenue, MS: R6E-3 (R6W-120B), Palo Alto, CA 94304, USA. Than.Hendricks@Roche.com
PMID: 19070486 DOI: 10.1016/j.bmcl.2008.11.060
Abstract

Isoquinoline-based non-nucleoside inhibitors of HCV NS5b RNA-dependent RNA-polymerase are described. The synthesis and structure-activity relationships are detailed, along with Enzyme and cellular activity.

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