2. Academic Validation
  3. Synthesis and evaluation of novel chloropyridazine derivatives as potent human rhinovirus (HRV) capsid-binding inhibitors

Synthesis and evaluation of novel chloropyridazine derivatives as potent human rhinovirus (HRV) capsid-binding inhibitors

  • Bioorg Med Chem. 2009 Jan 15;17(2):621-4. doi: 10.1016/j.bmc.2008.11.061.
Shi-Yong Fan 1,  Zhi-Bing Zheng,  Chun-Lai Mi,  Xin-Bo Zhou,  Hui Yan,  Ze-Hui Gong,  Song Li
Affiliations

Affiliation

  • 1 Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Beijing 100850, China.
PMID: 19091578 DOI: 10.1016/j.bmc.2008.11.061
Abstract

Human rhinovirus (HRV) is the most important etiologic agent causing common colds. No effective anti-HRV agents are currently available. In this paper we describe the synthesis and the evaluation of novel chloropyridazine derivatives (compounds 5a-g) as potent human rhinovirus (HRV) capsid-binding inhibitors. Results showed that compound 5e and 5f exhibited effective anti-HRV activity against HRV-2 and HRV-14. In addition, compound 5e and 5f showed lower cytotoxicity than Pirodavir.

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