2. Academic Validation
  3. Pestalofones A-E, bioactive cyclohexanone derivatives from the plant endophytic fungus Pestalotiopsis fici

Pestalofones A-E, bioactive cyclohexanone derivatives from the plant endophytic fungus Pestalotiopsis fici

  • Bioorg Med Chem. 2009 Jan 15;17(2):606-13. doi: 10.1016/j.bmc.2008.11.066.
Ling Liu 1,  Shuchun Liu,  Xulin Chen,  Liangdong Guo,  Yongsheng Che
Affiliations

Affiliation

  • 1 Key Laboratory of Systematic Mycology and Lichenology, Institute of Microbiology, Chinese Academy of Sciences, No. 13 Beiyitiao, Zhongguancun, Beijing 100080, People's Republic of China.
PMID: 19101157 DOI: 10.1016/j.bmc.2008.11.066
Abstract

Pestalofones A-E (1-5), five new cyclohexanone derivatives, have been isolated from cultures of the plant endophytic fungus Pestalotiopsis fici, along with the known compounds, isosulochrin (6), isosulochrin dehydrate (7), and iso-A82775C (8). The structures of 1-5 were determined by NMR spectroscopy, and the absolute configuration of 1 was assigned using the modified Mosher method. Compounds 1, 2, and 5 displayed inhibitory effects on HIV-1 replication in C8166 cells, whereas 3 and 5 showed significant Antifungal activity against Aspergillus fumigatus.

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