2. Academic Validation
  3. Discovery of novel small molecule cell type-specific enhancers of NF-kappaB nuclear translocation

Discovery of novel small molecule cell type-specific enhancers of NF-kappaB nuclear translocation

  • Bioorg Med Chem Lett. 2009 Feb 15;19(4):1191-4. doi: 10.1016/j.bmcl.2008.12.086.
Gangli Gong 1,  Yuli Xie,  Yidong Liu,  Alison Rinderspacher,  Shi-Xian Deng,  Yan Feng,  Zhengxiang Zhu,  Yufei Tang,  Michael Wyler,  Nathalie Aulner,  Udo Toebben,  Deborah H Smith,  Lars Branden,  Caty Chung,  Stephan Schürer,  Dusica Vidović,  Donald W Landry
Affiliations

Affiliation

  • 1 Department of Medicine, Columbia University, 650 W 168th Street, BB 1029, New York, NY 10032, USA.
PMID: 19136257 DOI: 10.1016/j.bmcl.2008.12.086
Abstract

An IKKbeta inhibitor reported to block NF-kappaB transcriptional activities in Jurkat T cells, was found to enhance NF-kappaB translocation in HUVEC cells. These studies suggested a noncanonical NF-kappaB signaling pathway independent of IKKbeta in HUVEC cells.

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