2. Academic Validation
  3. Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P. falciparum malaria parasites and HL-60 cancer cells

Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P. falciparum malaria parasites and HL-60 cancer cells

  • Bioorg Med Chem. 2009 Feb 1;17(3):1325-38. doi: 10.1016/j.bmc.2008.12.017.
James Chadwick 1,  Amy E Mercer,  B Kevin Park,  Richard Cosstick,  Paul M O'Neill
Affiliations

Affiliation

  • 1 Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD, UK.
PMID: 19136263 DOI: 10.1016/j.bmc.2008.12.017
Abstract

A series of artemisinin dimers incorporating a metabolically stable C-10 carba-linkage have been prepared, several of which show remarkable in vitro antimalarial activity (as low as 30 pM) versus Plasmodium falciparum and in vitro Anticancer activity in the micromolar to nanomolar range versus HL-60 cell lines.

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