2. Academic Validation
  3. Negative regulation of Toll-like receptor signaling pathway

Negative regulation of Toll-like receptor signaling pathway

  • Microbes Infect. 2009 Mar;11(3):321-7. doi: 10.1016/j.micinf.2008.12.011.
Jie Wang 1,  Yu Hu,  Wei Wen Deng,  Bing Sun
Affiliations

Affiliation

  • 1 Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
PMID: 19146978 DOI: 10.1016/j.micinf.2008.12.011
Abstract

TLRs are primary sensors of invading pathogens, recognizing conserved microbial molecules and activating signaling pathways that are pivotal to innate and adaptive immune responses. However, a TLR signaling pathway must be tightly controlled because its excessive activation can contribute to the pathogenesis of many human diseases. This review provides a summary of the different mechanisms that are involved in the negative regulation of TLR signaling pathways.

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