2. Academic Validation
  3. Cytotoxic guanidine alkaloids from Pterogyne nitens

Cytotoxic guanidine alkaloids from Pterogyne nitens

  • J Nat Prod. 2009 Mar 27;72(3):473-6. doi: 10.1021/np800612x.
Luis Octávio Regasini 1,  Ian Castro-Gamboa,  Dulce Helena Siqueira Silva,  Maysa Furlan,  Eliezer Jesus Barreiro,  Paulo Michel Pinheiro Ferreira,  Cláudia Pessoa,  Letícia Veras Costa Lotufo,  Manoel Odorico de Moraes,  Maria Claudia Marx Young,  Vanderlan da Silva Bolzani
Affiliations

Affiliation

  • 1 Institute of Chemistry, Nucley of Bioassay, Biosynthesis and Ecophysiology of Natural Products, NuBBE, Sao Paulo State University, UNESP, Araraquara, SP, Brazil.
PMID: 19159272 DOI: 10.1021/np800612x
Abstract

As part of a bioprospecting program aimed at the discovery of potential Anticancer drugs, two new guanidine-type Alkaloids, nitensidines D and E (1, 2), and the known pterogynine (3), pterogynidine (4), and galegine (5), were isolated from the leaves of Pterogyne nitens. The structures of 1 and 2 were established on the basis of spectroscopic data interpretation. These compounds were tested against a small panel of human Cancer cell lines. Compound 2 exhibited cytotoxicity for HL-60 (human myeloblastic leukemia) and SF-245 (human glioblastoma) cells.

Figures