2. Academic Validation
  3. Anti-AIDS agents, 3. Inhibitory effects of colchicine derivatives on HIV replication in H9 lymphocyte cells

Anti-AIDS agents, 3. Inhibitory effects of colchicine derivatives on HIV replication in H9 lymphocyte cells

  • J Nat Prod. 1991 Mar-Apr;54(2):632-7. doi: 10.1021/np50074a052.
H Tatematsu 1,  R E Kilkuskie,  A J Corrigan,  A J Bodner,  K H Lee
Affiliations

Affiliation

  • 1 Natural Products Laboratory, School of Pharmacy, University of North Carolina 27599.
PMID: 1919593 DOI: 10.1021/np50074a052
Abstract

A series of colchicine and isocolchicine derivatives were evaluated as inhibitors of HIV replication in H9 lymphocytes. Colchicine showed only very slight inhibition in the absence of toxicity, as measured by the therapeutic index (IC50/EC50). None of the derivatives inhibited HIV replication in the absence of toxicity.

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