1. Academic Validation
  2. Aromatase inhibitory fatty acid derivatives from the pollen of Brassica campestris L. var. oleifera DC

Aromatase inhibitory fatty acid derivatives from the pollen of Brassica campestris L. var. oleifera DC

  • J Asian Nat Prod Res. 2009;11(2):132-7. doi: 10.1080/10286020802573933.
Nian-Yun Yang 1 Kun Li Yi-Fang Yang Yong-Hui Li
Affiliations

Affiliation

  • 1 Department of Traditional Chinese Medicine, Shanghai Institute of Pharmaceutical Industry, Shanghai, China.
Abstract

Two new fatty acid derivatives, 9Z,12Z,15Z-octadecatrienoic acid sorbitol ester (1) and (10,11,12)-trihydroxy-(7Z,14Z)-heptadecadienoic acid (2), were isolated from the pollen of Brassica campestris L. var. oleifera DC., along with the four known fatty acid derivatives, 9Z,12Z,15Z-octadecatrienamide, N-(2-hydroxyethyl) (3), hexadecanoic acid sorbitol ester (4), 15,16-dihydroxy-9Z,12Z-octadecadienoic acid (5), and 9Z,12Z,15Z-octadecatrienoic acid 2,3-dihydroxypropyl ester (6). Their structures were elucidated by extensive spectroscopic analysis, including 1D- and 2D-NMR as well as HR-ESI-MS experiments. All compounds were tested using a noncellular aromatase assay, and the results showed that some compounds possessed strong inhibitory activity.

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