Porphyrins containing nitric oxide donors: Synthesis and cancer cell-oriented NO release

Bioorg Med Chem Lett. 2009 Mar 15;19(6):1647-9. doi: 10.1016/j.bmcl.2009.02.005.

Wukun Liu ¹, Chaozhou Liu, Changjun Gong, Weiying Lin, Cancheng Guo

Affiliations

Affiliation

1 College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, PR China.

PMID: 19233650 DOI: 10.1016/j.bmcl.2009.02.005

Abstract

Four novel porphyrins containing nitric oxide (NO) donors were synthesized, and the structures of all the products were characterized by IR, UV-vis, (1)H NMR, and elementary analysis. Interestingly, these new compounds not only were able to release NO, but also showed Cancer cell-oriented accumulation. Higher accumulation of these new porphyrins containing NO donors in BEL-7402 liver Cancer cells than in L-02 liver normal cells was corroborated by UV-vis spectroscopy. The biological activity of these porphyrins against BEL-7402 liver Cancer cells was tested with a MTT assay. The studies indicated that they had more effective killing of BEL-7402 liver Cancer cells than that of L-02 liver normal cells, and they had similar activity against MCF-7 breast Cancer cells when compared to 5-fluorouracil in the absence of light.

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