Acylated iridoids with cytotoxicity from Valeriana jatamansi

J Nat Prod. 2009 Apr;72(4):650-5. doi: 10.1021/np800716f.

Sheng Lin ¹, Yun-Heng Shen, Hui-Liang Li, Xian-Wen Yang, Tao Chen, Long-Hai Lu, Zheng-Sheng Huang, Run-Hui Liu, Xi-Ke Xu, Wei-Dong Zhang, Hui Wang

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Affiliation

1 Department of Phytochemistry, College of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China.

PMID: 19245261 DOI: 10.1021/np800716f

Abstract

Thirteen new acylated Iridoids, jatamanvaltrates A-M (1-13), together with nine known valepotriates (14-22), were isolated from the whole Plants of Valeriana jatamansi (syn. Valeriana wallichii). The structures of these new compounds were assigned by detailed interpretation of spectroscopic data. Jatamanvaltrates D (4) and H (9) are the first examples of naturally occurring valepotriates containing an o-hydroxybenzoyloxy moiety at C-10. All isolated compounds were tested for their cytotoxicity against lung adenocarcinoma (A549), metastatic prostate Cancer (PC-3M), colon Cancer (HCT-8), and hepatoma (Bel7402) cell lines.

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